![]() ![]() Nevertheless, these existing efforts are not able to achieve wide coverage of the rapidly growing scientific corpus (over 1.3 million new PubMed articles per year Bornmann and Mutz, 2015 Cordero et al., 2016), arguing for the development of more scalable and sustainable approaches ( Attwood et al., 2015 Imker, 2018).įor reasons of efficiency and accuracy, structured knowledge of biomedical discoveries could be provided directly by the original authors of research reports, rather than post-hoc, through the curation efforts of knowledge base teams. These computational tools can access the increasing amounts of pathway and interaction data ( Bader et al., 2006) collected from organizations that either centrally curate the literature ( Gene Ontology Consortium, 2015 Jassal et al., 2020) or crowdsource pathway information from the community of researchers ( Slenter et al., 2018). To manage, visualize and interpret the large amount of available pathway information, researchers require computational tools such as pathway information resources, structured data representation standards and analysis software ( Demir et al., 2010 Franz et al., 2016 Jassal et al., 2020 Pratt et al., 2015 Rodchenkov et al., 2020 Shannon et al., 2003). This information can be used for experimental design, interpretation of genomics data ( Khatri et al., 2012), understanding of disease mechanisms ( Chinen et al., 2016 Santos et al., 2014), and identification of therapeutic targets ( Mack et al., 2014). Princess Margaret Cancer Centre, University Health Network, Canada īiological pathways organize sets of molecular interactions and reactions that underlie cellular processes.The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Canada.Department of Computer Science, Department of Molecular Genetics, University of Toronto, United States. ![]() Laboratory of Systems Pharmacology, Harvard Medical School, United States.Broad Institute, Massachusetts Institute of Technology, Harvard University, United States.Department of Data Sciences, Dana-Farber Cancer Institute, United States.Department of Informatics, Technische Universität München, Germany.Department of Systems Biology, Harvard Medical School, United States.Department of Cell Biology, Harvard Medical School, United States.Computer Science Department, University of Massachusetts Boston, United States.Computational Biology Program, Oregon Health and Science University, United States.The Donnelly Centre, University of Toronto, Canada. ![]()
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